The rapid pace of progress in biotechnology, the increased number of novel therapeutic agents and the progressively greater complexity of early clinical trials have led to a need for more physicians with special skills in drug development. The major objective of the ADTTP is to provide medical oncologists advanced training in state-of-the-science principles and technologies of developmental therapeutics by utilizing the unique resources available within the NCI. The program will provide an excellent opportunity to refine skills in clinical investigation including novel strategies for trial design and methodology, protocol development, execution, and monitoring, conformity with ethical standards, and formulation of attainable and pertinent laboratory correlatives. There will be ample opportunity to interact and draw on the expertise of other intramural NIH and extramural investigators and scientists to broaden knowledge of drug development.