Scientist, Protein Engineering

Vancouver, British Columbia (CA)
Competitive salary and benefits
Jun 18, 2017
Jul 27, 2017
Full Time

Scientist, Protein Engineering

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Key Responsibilities

  • Performs research and feasibility studies into proposed protein-engineering projects.
  • Designs expression constructs for antibody and protein production.
  • Plans and develops purification and assay protocols.
  • Participates in the development of plans, schedules and costs of assigned projects/programs.
  • Liaises with laboratory personnel and CRO staff to follow-up on the protein expression and screening for biophysical and bioactivity of the engineered molecules.
  • Prepares reports on assigned projects for internal and external use, makes presentations to team and contributes to technical journals.
  • Participates in the preparation of patents and publications.
  • Checks, organizes, analyzes and reports data produced. Prepares reports, documents and dossiers.
  • Liaises with laboratory personnel and CRO staff to follow-up on the protein expression and screening for biophysical and bioactivity of the engineered molecules.
  • Fosters effective and collaborative working relationships with fellow employees, management and external partners.

Education and Experience

PhD in a scientific discipline (Biochemistry, Immunology, Molecular or Cellular Biology or related field), and a minimum of 2 to 5 years’ related experience (may include post-doctoral experience) or an equivalent combination of education and experience.

Skills and Abilities

  • Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional team. Ability to establish and maintain effective working relationships.
  • Experience in protein expression, purification, biochemical and bioactivity characterization using techniques such as ELISA, SPR, FACS, etc.
  • Experience in a least some important biophysical characterization techniques such as UPLC/SEC, DSC/DSF, AUC, DLS, LC-MS, etc.
  • Understanding of protein chemistry and experience in rational protein design and engineering.
  • Experience with molecular model building, simulation and visualizing packages (AMBER, CCP4, COOT, etc.)
  • Meticulous organization, record keeping and reporting.
  • Good analytical and problem solving skills, incorporating integrity in all decision making.
  • Ability to manage concurrent deliverables and work effectively in a challenging, milestone-driven environment.
  • Effective oral and technical/scientific writing skills. Previous experience presenting scientific data to internal audiences.

Why Work for Us?

Zymeworks’ employees are passionate, engaged and extremely motivated to succeed. We are excited by the cutting-edge science and technology, the endless possibilities this union holds and the sheer opportunity to be a part of something big. To learn more about Zymeworks Inc. and our current openings, please visit our website at

We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

How to Apply

If you are interested in this challenging and rewarding position, please email your resume and cover letter to with “Scientist, Protein Engineering” in the subject line.